Statistics - explanations and formulas

Statistical Significance versus Clinical Significance

Statistical significance tell us if the difference between the two interventions is due to chance, or the difference is the intervention under investigation.

In research terms, statistical significance is a measure of the probability of the null hypothesis being true compared to the acceptable level of uncertainty regarding the true answer.


Statistical Significance

Tenny S, Abdelgawad I. Statistical Significance. [Updated 2022 Nov 21]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available from:


Clinical Significance is the extent to which a study result is judged to be meaningful in relation to the diagnosis or treatment of disorders. It measures the extent that a change can create a meaningful response for the patient.